Probabilities of adverse reactions to Dog Vaccinations are very small, and symptoms will appear after few minutes of being inoculated. Normally, symptoms can be reverted through an adrenaline shot. It's very difficult your dog can develop the disease, when vaccinated with living bacteria; for instance, if few days later, he suffers of distemper, he will probably was already incubated the disease before inoculation. In other words, vaccine cannot be effective, if the disease was already in the body.
Is there a possibility to inoculate orphan puppies? These are in great danger, if they have not received a protective colostrum, specially in pounds where there are other . In these cases, a hyper immune serum is preferable, cause their own immunology system cannot produce antibodies in their first months of life. The puppy can be vaccinated for the first time, approximately a month after the serum.